Signal Transduction Reagents and Kits
Enzo Life Sciences (2R,4R)-APDC (1mg). CAS: 169209-63-6
Selective agonist for group II mGluRs. Inhibits the NADPH-oxidase dependent ROS system. Alternative name: LY-314,593, (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid. Purity: ≥98% (HPLC). Solubility: Soluble in water. Long Term Storage: Ambient.
Apexbio Technology LLC Zolmitriptan 139264-17-8 100mg
Zolmitriptan (CAS 139264-17-8) is a synthetic small molecule that functions as a selective agonist of serotonin 5-HT1B and 5-HT1D receptors By stimulating these receptors zolmitriptan modulates trigeminovascular neurotransmission leading to cranial vasoconstriction and inhibition of pro-inflammatory neuropeptide release These mechanisms underlie its ability to acutely alleviate migraine attacks both with and without aura as well as cluster headaches In biomedical research zolmitriptan serves as a tool compound for investigating serotonergic signaling pathways involved in nociception and vascular regulation associated with headache disorders
Echelon Biosciences Research Labs PI(4,5)P2 PolyPIPosomes 0.25 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
Echelon Biosciences Research Labs PI(5)P PolyPIPosomes 0.1 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
CPC Scientific Glp-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH (trifluoroacetate salt) 1MG
Nonapeptide capable of inhibiting the conversion of angiotensin I to angiotensin II, in vitro and in vivo. Bradykinin Potentiator.SEQUENCE: Glp-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: Glp-WPRPQIPPMOLECULAR FORMULA: C53H76N14O12MOLECULAR WEIGHT: 1101.3STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [35115-60-7]SYNONYMS: RESEARCH AREA: CardiovascularREFERENCES:M.A. Ondetti et al., Biochemistry, 10, 4033 (1971)H.S. Cheung and D.W. Cushman, Biochim. Biophys. Acta, 293, 451 (1973)L.C. Martin et al., Biochem. J., 184, 713 (1979)D.I. Marlborough et al., Arch. Biochem. Biophys., 210, 43 (1981)SKU(s): ACEI-001A, ACEI-001B, ACEI-001C
Echelon Biosciences Research Labs BODIPY FL-PI(3,5)P2 100 ug
BODIPY FL PI(3,5)P2 (BODIPY FL Phosphatidylinositol 3,5-bisphosphate) is a water soluble analog of PI(3,5)P2 labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). This item is non returnable
eMolecules 364-98-7 | DIAZOXIDE | AstaTech | MFCD00078578 | 230.670 | C8H7ClN2O2S | 95.000 | CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 | 1g | 302799229
DIAZOXIDE | AstaTech | 364-98-7 | MFCD00078578 | 230.670 | C8H7ClN2O2S | 95.000 | CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 | 1g | 302799229
CPC Scientific Ac-Tyr-Val-Lys-Asp-CHO 1MG
Affinity ligand for interleukin-1b converting enzyme. Slow binding caspase-1 (ICE) inhibitor with low selectivity.SEQUENCE: Ac-Tyr-Val-Lys-Asp-CHOONE-LETTER SEQUENCE: Ac-YVKD-CHOMOLECULAR FORMULA: C26H39N5O8MOLECULAR WEIGHT: 549.6STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [147821-01-1]SYNONYMS: RESEARCH AREA: ApoptosisREFERENCES:T.L. Graybill et al., Int. J. Peptide Protein Res., 44, 173 (1994)N.A. Thornbery et al., Nature, 356, 768 (1992)SKU(s): CASP-015A
Enzo Life Sciences Ac-Leu-Leu-Nle-al (5 mg) CAS: 110044-82-1
Cysteine protease inhibitor. Alternative Name: ALLN, Calpain inhibitor I, Ac-LL-norleucinal. Formula: C20H37N3O4. MW: 383.5. CAS: 110044-82-1. Purity: ≥95% (HPLC). Sequence N-Acetyl-Leu-Leu-Nle-CHO. Appearance: White powder. Solubility: Soluble in ethanol (5 mg/ml) or DMSO (10 mg/ml). Long Term Storage: -20°C. Handling: Store dry and protect from light.
Aat Bioquest Calbryte 520 AM (10x50 ug)
The intracellular calcium flux assay is a widely used method in monitoring signal transduction pathways and high throughput screening of G proteinquotcoupled receptors GPCRs and calcium channel targets. This catalog is for 10x50 ug.
Enzo Life Sciences ICRF-193 (1mg). CAS: 21416-68-2
A topoisomerase II inhibitor that does not cause DNA damage. Induces apoptosis in several cell lines including K562 and Molt-4 cells. Induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Alternative name: Meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione). Purity: ≥95% (HPLC). Solubility: Soluble in DMSO (4mg/ml). Long Term Storage: -20°C.
Sigma Aldrich Fine Chemicals Biosciences Zolmitriptan >=98% (HPLC) | 139264-17-8 | MFCD00871503 | 50MG
Zolmitriptan >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 287.36 | 139264-17-8 | MFCD00871503 | 50MG
BPS Bioscience Inc SBE Reporter HEK293 Cell Line, 2 vials of frozen cells, 2 x 10^6 cells in 1 ml of cell freezing medium, ~1.5 x 10^6 cells in 1 ml of 10% DMSO, >1 x 10^6 cells in 1 ml of freezing medium, adherent growth properties
SBE Reporter HEK293 Cell Line, 2 vials of frozen cells, 2 x 10^6 cells in 1 ml of cell freezing medium, ~1.5 x 10^6 cells in 1 ml of 10% DMSO, >1 x 10^6 cells in 1 ml of freezing medium, adherent growth properties
Selleck Chemical LLC SB202190 (FHPI) 100mg 152121-30-7
SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38?/? with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Echelon Biosciences Research Labs 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) 1 mg
1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VgVd T-cell activator identified. This item is non returnable