Signal Transduction Reagents and Kits
Echelon Biosciences Research Labs Gamma Secretase Inhibitor - 5 mg, CAS#: 133407-83-7
Gamma Secretase Inhibitor - 5mg , Z-Leu-Leu-Nle-CHO Category/Application: Enzyme Substrates This item is non returnable
Apexbio Technology LLC Aurora Kinase Inhibitor III 879127-16-9 1mg
Aurora Kinase Inhibitor III (CAS 879127-16-9) is a selective small molecule inhibitor targeting Aurora A kinase It acts by binding to the ATP-binding site of Aurora A thereby suppressing its enzymatic activity with an IC50 of 42 nM The compound exhibits substantially lower inhibitory potency against epidermal growth factor receptor (EGFR) with an IC50 greater than 10 M Aurora Kinase Inhibitor III serves as a useful chemical probe for investigating Aurora A-mediated processes including mitotic regulation cell cycle progression and associated signaling pathways and supports studies exploring the role of Aurora A in oncogenesis
Takara Bio Lenti-X GoStix Plus, 10 Minute quantitative lentiviral titer tests
Lenti-X GoStix Plus; Quantify lentivirus titer in 10 minutes; 50 Tests
Sigma Aldrich Fine Chemicals Biosciences Oleoyl-L--lysophosphatidic acid sodium salt 98, solid, 22556-62-3, MFCD00133427
Oleoyl-L--lysophosphatidic acid sodium salt 98, solid
Echelon Biosciences Research Labs PI(4)P DIC8 AMMONIUM 100 ug
Phosphatidylinositol 4-phosphate diC8 (PI(4)P diC8) is a synthetic, purified dioctanoyl PI(4)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable
Echelon Biosciences Research Labs PI(5)P DIC8 AMMONIUM SALT 500 ug
Phosphatidylinositol 5-phosphate diC8 (PI(5)P diC8) is a synthetic, purified dioctanoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases. This item is non returnable
Enzo Life Sciences Z-prolyl-prolinal (25mg). CAS: 86925-97-5
A potent and selective inhibitor of prolyl endopeptidase (PEP/PREP/POP, EC 3.4.21.26). Ki=0.35 nM for mouse brain enzyme. Inhibits the cleavage of arginine-vasopressin, gonadotropin-releasing hormone, and other peptides. Alternative name: Z-PP-CHO. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Abcam Citrate Assay Kit
Citrate Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Abcam Angiotensin Converting Enzyme 1 (ACE1) Inhibitor Screening Kit (Colorimetric)
Angiotensin Converting Enzyme 1 (ACE1) Inhibitor Screening Kit (Colorimetric)
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences MMP-Inhibitor profiling kit, fluorometric (1x96wells)
A QUANTIZYME Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a sensitive fluorogenic substrate . Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Applications: Fluorescent detection, HTS Activity assay.
Medchemexpress LLC Veratridine | 71-62-5 | 10 MG
Veratridine is a plant neurotoxin and a voltage-gated sodium channel (VGSCs) agonist. It inhibits the peak current of Nav1.7 with an IC50 of 18.39 μM. It regulates sodium ion channels by activating them, preventing channel inactivation, and increasing sodium ion flow. This product is for research use only.
- Plant neurotoxin
- Voltage-gated sodium channels (VGSCs) agonist
- Inhibits peak current of Nav1.7
- Regulates sodium ion channels by activation
- Prevents channel inactivation
- Increases sodium ion flow
Medchemexpress LLC Tulobuterol (C-78 free base) | 41570-61-0 | 99.7% | 50 MG
Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. It is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.
- Decreases RV14 RNA levels at 1 day and 3 days after infection in human tracheal epithelial cells.
- Significantly lowers sICAM-1 concentrations in cell supernatants.
- Reduces the number and fluorescence intensity of acidic endosomes.
- Decreases RV14 infection-induced secretion of IL-1β, IL-6, and IL-8.
- Produces a small but significant reduction in p50, p65, and c-Rel of NF-κB induced by RV14 infection.
- Maintains diaphragm muscle contractility for over 24 hours in a mouse model of sepsis.
Echelon Biosciences Research Labs BODIPY FL PI(3)P 100 ug
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Enzo Life Sciences Lysophosphatidic acid, (5mg), CAS Number: 325465-93-8
LPA receptor ligand. Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative Name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Formula: C21H40O7P . Na. MW: 458.5. CAS Number: 325465-93-8. Purity: ≥98% (TLC). Appearance: Waxy solid. Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Use/Stability: Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month. Long Term Storage: -20°C